Artificial Bone Substitute of MGSB and Hyaluronate Hydrogels
نویسندگان
چکیده
A novel artificial bone substitute composed of bioactive MegaGen synthetic bone (MGSB) and hyaluronate (HA) hydrogels was successfully developed for bone tissue engineering applications. HA is known to play important roles in bone regeneration due to its angiogenic and osteoconductive characteristics. Accordingly, HA hydrogel was designed to supply HA continuously for effective bone regeneration by its controlled degradation in vivo. Synchrotron X-ray bio-imaging clearly visualized 3-dimensional micron scale morphologies of effectively regenerated bones by the bone substitute of MGSB/Hyaluronate-Cystamine hydrogels implanted to the calvarial critical size bone defects in New Zealand white rabbits.
منابع مشابه
Synchrotron X-ray bioimaging of bone regeneration by artificial bone substitute of MegaGen Synthetic Bone and hyaluronate hydrogels.
Synchrotron X-ray bioimaging was successfully carried out to observe bone regeneration by a novel artificial bone substitute of bioactive MegaGen Synthetic Bone (MGSB) and hyaluronate (HA) hydrogels. A biphasic calcium phosphate of MGSB was prepared by chemical precipitation method, with a porous spherical morphology. On the basis of the fact that HA plays important roles in bone regeneration a...
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